Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via PHACTR1 Regulation
Kai Yi Tay, Hannah Su-Ann Wee, Nhi Le Uyen Nguyen, Matias Ilmari Autio, Vanessa Kristina Wazny, Khang Leng Lee, Darwin Tay, Yuting Wang, Xu Gao, Chew‐Kiat Heng, Mark Y. Chan, Roger Foo, Jimmy Lee, Marie Chiew Shia Loh, Christine Cheung
This study identifies rs6903956 as a CAD risk variant that regulates endothelial dysfunction through PHACTR1 and EDN1 expression via HOXA4 and MEIS1 binding.
bioRxiv · May 11, 2025 · PreprintMolecular Biology