Marie Chiew Shia Loh

This study investigates how menopause alters Malassezia fungal populations on skin and their impact on inflammation and skin health in Asian women.

This paper develops and validates multi-ancestry polygenic risk scores for type 2 diabetes prediction and complications across diverse populations.

The paper identifies USP18 as a negative regulator of interferon response at a lupus risk locus through trans-eQTL analysis in lymphoblastoid cell lines.

This study identifies rs6903956 as a CAD risk variant that regulates endothelial dysfunction through PHACTR1 and EDN1 expression via HOXA4 and MEIS1 binding.

The paper identifies prevalent skin microbiome configurations (dermotypes) across body sites and links them to host factors and disease risk.

The paper identifies DNA methylation biomarkers predictive of Type-2 diabetes in Asian populations and shows their utility in risk stratification.

The paper investigates how life stages affect the human skin microbiome and lipid mediators, finding microbial correlations with lipid profiles and cytokine production.

This study identifies 194 epigenome-wide significant CpGs associated with dilated cardiomyopathy (DCM) and links them to cardiac gene expression and cardiovascular risk factors.

The paper presents AIDA, a diverse single-cell RNA-seq atlas of immune cells, revealing sub-continental diversity impacts on immune cell properties and identifying functional genetic variants.

This study identifies DNA methylation changes associated with extreme obesity and finds causal effects on obesity and metabolic disturbances using Mendelian Randomisation.

This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

The paper identifies genetic variants associated with heart failure by analyzing histone acetylation QTLs in human heart tissue.

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.