Matias Ilmari Autio

Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via PHACTR1 Regulation

This study identifies rs6903956 as a CAD risk variant that regulates endothelial dysfunction through PHACTR1 and EDN1 expression via HOXA4 and MEIS1 binding.

Highly enhanced transgene integration in human pluripotent stem cells by serine integrase BxbI

This study enhances transgene integration in human pluripotent stem cells using BxbI integrase with codon optimization and other modifications, achieving up to 20-fold higher efficiency.

Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease

Gene neighbourhood integrity disrupted by CTCF loss in vivo

This study shows that loss of CTCF in mouse cardiomyocytes disrupts gene neighbourhoods, leading to ectopic enhancer-promoter interactions and heart failure.

Disease and phenotype relevant genetic variants identified from histone acetylomes in human hearts

The paper identifies genetic variants associated with heart failure by analyzing histone acetylation QTLs in human heart tissue.

Accelerated human liver progenitor generation from pluripotent stem cells by inhibiting formation of unwanted lineages

This study accelerates the generation of human liver progenitors from pluripotent stem cells by blocking unwanted lineage formation and manipulating temporal signals.