Roger Pocock

Loss of sphingomyelin synthase-1 does not cause egg retention or locomotion defects in Caenorhabditis elegans

The paper investigates the role of sphingomyelin synthase-1 in C. elegans and finds that its loss does not cause egg retention or locomotion defects, suggesting potential background mutations in the studied mutant.

Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress

The paper shows that GCY-9 in C. elegans carbon dioxide sensing neurons primes mitochondrial stress response to enhance metabolic resilience under starvation.

Mediator-29 Limits Caenorhabditis elegans Fecundity

This study shows that MDT-29 in C. elegans germ cells regulates fecundity by affecting stem cell numbers and apoptosis.

Tbc1d15 knockdown in vivo alleviates α-synuclein-induced neurotoxicity by promoting autophagy.

This study shows that reducing Tbc1d15 in mice enhances autophagy, reduces α-synuclein toxicity, and improves motor function in a Parkinson's disease model.

Nuclear Factor-Y is a Pervasive Regulator of Neuronal Gene Expression

This study identifies NF-Y as a key regulator of both neuron-type-specific and pan-neuronal gene expression through direct and indirect mechanisms.

A neuro-intestinal circuit controls mitochondrial dynamics and stress resistance

The paper shows that GABA inhibits and acetylcholine promotes the mitochondrial stress response in C. elegans intestine via a neuro-intestinal circuit.

Characterization of the Doublesex/MAB-3 transcription factor DMD-9 in Caenorhabditis elegans

This study characterizes DMD-9 expression and regulatory mechanisms in C. elegans, finding it is cell-autonomously regulated in flp-19 neurons and likely acts redundantly in neuronal development.

Conditional degradation of UNC-31/CAPS enables spatiotemporal analysis of neuropeptide function

This paper develops a tool to conditionally degrade UNC-31 in C. elegans to study neuropeptide function with spatiotemporal precision, revealing specific defects in egg-laying, locomotion, and vesicle release.

An intestinal sphingolipid promotes neuronal health across generations

The paper shows that maternal diet-induced intestinal sphingolipid biosynthesis reduces neurodegeneration in offspring across generations in C. elegans.

Diet-responsive Transcriptional Regulation of Insulin in a Single Neuron Controls Systemic Metabolism

The paper shows that ETS-5 in C. elegans BAG neurons regulates INS-1 expression, linking neuronal activity to systemic metabolism through diet-induced changes.

Atypical TGF-beta Signaling Controls Neuronal Guidance in Caenorhabditis elegans

The paper identifies an atypical TGF-beta signaling pathway in C. elegans that regulates neuronal guidance through SMA-6 and NLR-1 interactions.

Functional Recovery of the Germ Line Following Splicing Collapse

This study identifies MOG-7 as a pre-mRNA splicing factor in C. elegans, showing that its loss causes splicing defects and sterility, but functional recovery occurs through apoptosis and progenitor zone proliferation.

Notch-Directed Germ Cell Proliferation Is Mediated by Proteoglycan-Dependent Transcription

The paper identifies a mechanism by which Notch receptor GLP-1 expression is regulated through a proteoglycan-dependent interaction involving a transcription factor and calcium signaling in C. elegans.

Experimental investigation of Caenorhabditis elegans motility using micro-PIV

This study investigates how a mutation in mir-1 affects the motility of C. elegans by analyzing kinematic parameters and power output across age.

Harmonization of L1CAM Expression Facilitates Axon Outgrowth and Guidance of a Motor Neuron

The paper shows that CTBP-1 represses SAX-7/L1CAM to regulate SMD motor neuron axon development, with LAD-2 acting as a parallel factor in axon guidance.

Distinct CED-10/Rac1 Domains Confer Context-Specific Functions in Neuronal Development

The paper identifies a specific glycine residue in CED-10/Rac1 that is critical for axon outgrowth but not guidance, revealing domain-specific functions in neuronal development.

Protein Disulfide Isomerases Control the Secretion of Wnt proteins

This study identifies PDI-1 as a key factor in Wnt protein secretion in C. elegans and shows its conserved role in human cells.

Hub connectivity, neuronal diversity, and gene expression in the C. elegans connectome

The paper shows that hub neurons in the C. elegans connectome have tightly coupled gene expression, which is linked to their role as command interneurons regulating locomotion.