David Chaim Rubinsztein

ATG-18 drives longevity in an HLH-30-dependent manner

This study shows that ATG-18 overexpression extends C. elegans lifespan and improves stress resilience through the HLH-30 transcription factor, while also revealing a temporal-specific effect on heat stress survival.

Multimodal brain cell atlas across the adult macaque lifespan

The paper constructs a multimodal brain cell atlas of adult macaques across their lifespan, revealing aging-related molecular changes and identifying aging hotspots and regulatory loci.

Tbc1d15 knockdown in vivo alleviates α-synuclein-induced neurotoxicity by promoting autophagy.

This study shows that reducing Tbc1d15 in mice enhances autophagy, reduces α-synuclein toxicity, and improves motor function in a Parkinson's disease model.

ULK-mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn’s mutant

This study shows ULK1 phosphorylates ATG16L1, enhancing wildtype function but destabilizing the Crohn’s disease-associated mutant, thereby affecting xenophagy.

Analysis of shared heritability in common disorders of the brain

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.