Nakul Ravi Raval

This study uses SPECT/CT to compare CSF dynamics in pigs and rats under different anesthetics, finding species- and anesthesia-specific differences in tracer distribution and clearance.

This study shows that reducing Tbc1d15 in mice enhances autophagy, reduces α-synuclein toxicity, and improves motor function in a Parkinson's disease model.

This paper develops kinetic models for PET displacement studies to estimate target occupancy from a single scan, showing good agreement with traditional methods.

This paper evaluates the PET radiotracer (d3)-[11C]MODAG-001 in pigs to detect α-synuclein aggregates, showing increased binding in regions with α-synuclein pre-formed fibrils and Alzheimer's homogenate.

The paper develops a pig model for testing PET radioligands targeting cerebral protein aggregates, validated using [11C]PIB uptake in injected regions.

This study compares [11C]UCB-J and [18F]FDG PET in a 6-OHDA rat model of Parkinson's disease, finding divergent changes in synaptic density and metabolic function in CSTC circuits.