Sébastien Besseau

The paper identifies MDR proteins as regulators of geissoschizine biosynthesis, enhancing activity and diversifying stereochemical outputs through ternary complex formation with GS and SGD.

This study investigates the evolutionary diversification of CYP71D enzymes in Gentianales, showing how gene duplication and neofunctionalization expanded MIA chemical diversity.

This paper identifies and characterizes pachysiphine synthase genes in Tabernaemontana elegans using genome sequencing and computational analysis, enabling engineered yeast production of MIAs.

The paper evaluates correlation methods for constructing co-expression networks using microarray and RNA-seq data in Arabidopsis thaliana, finding that PCC with HRR performs best for global networks and pathway-level correlations.