Author

Stefano Pascarelli

Okinawa Institute of Science and Technology Graduate UniversityORCID 0000-0002-5529-3774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Paola LaurinoiD· 3 shared Adrian AltenhoffiD· 1 shared Alessandro BevilacquaiD· 1 shared Alex Warwick VesztrocyiD· 1 shared Ali Yazdizadeh KharraziiD· 1 shared Amy Q. SheniD· 1 shared Christophe DessimoziD· 1 shared Dalmira MerzhakupovaiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBioinformatics

Paola LaurinoORCID

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Author profile →

4 papers

Recent·Most cited

Orthology inference at scale with FastOMA

Sina Majidian, Yannis Nevers, Ali Yazdizadeh Kharrazi, Alex Warwick Vesztrocy, Stefano Pascarelli, David Moi, Natasha Glover, Adrian Altenhoff, Christophe Dessimoz

FastOMA scales orthology inference to handle large genome datasets efficiently while maintaining accuracy.

Nature Methods · Jan 3, 2025Peer-reviewedBioinformatics

Enzyme Activity Regulates Substrate Diffusion by Modulating Viscosity in Crowded Milieu

Alessandro Bevilacqua, Mauricio Rios Maciel, Mark V. Sullivan, Stefano Pascarelli, Mirco Dindo, Amy Q. Shen, Paola Laurino

This study shows enzymatic activity reduces viscosity in crowded environments, enhancing substrate diffusion by up to three-fold through disruption of non-covalent interactions.

bioRxiv · Sep 28, 2024 · PreprintBiochemistry

Identification of residue inversions in large phylogenies of duplicated proteins

Stefano Pascarelli, Paola Laurino

The paper identifies residue inversions in protein phylogenies to uncover functional divergence after gene duplication, finding 19 such sites in EGFR sequences across 88 fish species.

PLoS Computational Biology · Apr 4, 2022Peer-reviewedBioinformatics

Binding of single-mutant epidermal growth factor (EGF) ligands alter the stability of the EGF receptor dimer and promote growth signaling

Stefano Pascarelli, Dalmira Merzhakupova, Gen‐ichiro Uechi, Paola Laurino

This study shows that single-mutant EGF ligands alter EGFR dimer stability and signaling, supporting biased signaling theory.

Journal of Biological Chemistry · Jun 11, 2021Peer-reviewedBioinformatics