Gen‐ichiro Uechi

The paper identifies a triple-deletion mutant of SRC kinase that alters activation loop dynamics, leading to changes in substrate preference and signaling outcomes.

This study engineers Oxalate decarboxylase to improve its activity and stability for medical applications in hyperoxaluria treatment.

This study shows that single-mutant EGF ligands alter EGFR dimer stability and signaling, supporting biased signaling theory.