Author

Conny Tümmler

Karolinska InstitutetORCID 0000-0002-5530-4752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alena MalyukovaiD· 1 shared Alessandro Simone BordonaroiD· 1 shared Andrä BrunneriD· 1 shared Ervelina Dalani· 1 shared Georgios MermelekasiD· 1 shared Glenn M. MarshalliD· 1 shared Janith Seniveratne· 1 shared Jiayu XiaoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alena MalyukovaORCID

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1 paper

Recent·Most cited

Targeting the FBXL12-FANCD2 Pathway Disrupts Replication Stress Tolerance in MYCN-Driven Neuroblastoma

Jinjiang Chou, Alena Malyukova, Alessandro Simone Bordonaro, Krzysztof Dygon, Lena Litzenburger, Ervelina Dalani, Jiayu Xiao, Conny Tümmler, Georgios Mermelekas, Janith Seniveratne, Magdalena Paolino, Juha Rantala, Lukas M. Orre, Glenn M. Marshall, John Inge Johnsen, , Olle Sangfelt

This study identifies the FBXL12-FANCD2 pathway as a vulnerability in MYCN-driven neuroblastoma, showing its role in replication stress tolerance and potential as a therapeutic target.

bioRxiv · Aug 31, 2026 · PreprintCancer Biology