Author

Olle Sangfelt

Karolinska InstitutetORCID 0000-0002-0316-0195Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Andrä BrunneriD· 2 shared Alena MalyukovaiD· 1 shared Alessandro Simone BordonaroiD· 1 shared Conny TümmleriD· 1 shared Daniel BexelliD· 1 shared Diandra DaumilleriD· 1 shared Ervelina Dalani· 1 shared Georgios MermelekasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Andrä BrunnerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Targeting the FBXL12-FANCD2 Pathway Disrupts Replication Stress Tolerance in MYCN-Driven Neuroblastoma

Jinjiang Chou, Alena Malyukova, Alessandro Simone Bordonaro, Krzysztof Dygon, Lena Litzenburger, Ervelina Dalani, Jiayu Xiao, Conny Tümmler, Georgios Mermelekas, Janith Seniveratne, Magdalena Paolino, Juha Rantala, Lukas M. Orre, Glenn M. Marshall, John Inge Johnsen, , Olle Sangfelt

This study identifies the FBXL12-FANCD2 pathway as a vulnerability in MYCN-driven neuroblastoma, showing its role in replication stress tolerance and potential as a therapeutic target.

bioRxiv · Aug 31, 2026 · PreprintCancer Biology

De novo Design of Macrocyclic Molecular Glues

Andrä Brunner, Krzysztof Wierbiłowicz, Diandra Daumiller, Daniel Bexell, Kasper Karlsson, Olle Sangfelt, Patrick Bryant

This paper introduces EvoBind-multimer, a deep learning framework for designing molecular glues from protein sequences, demonstrating its ability to recruit E3 ligases to oncoproteins and showing context-dependent functionality.

bioRxiv · Aug 22, 2026 · PreprintBioinformatics