Lukas M. Orre

Targeting the FBXL12-FANCD2 Pathway Disrupts Replication Stress Tolerance in MYCN-Driven Neuroblastoma

This study identifies the FBXL12-FANCD2 pathway as a vulnerability in MYCN-driven neuroblastoma, showing its role in replication stress tolerance and potential as a therapeutic target.

Mass spectrometry-based proteomics delivers in-depth proteome profiling of FFPE lung cancer biopsies from single glass slides

This study shows that mass spectrometry-based proteomics can profile FFPE lung cancer biopsies from single glass slides, providing actionable protein and biomarker data from limited clinical material.

Pathway activation model for personalized prediction of drug synergy

This paper introduces DIPx, a model predicting drug synergy using pathway activation scores, showing better performance than existing methods on both known and novel drug combinations.

Strong binding activity of few transcription factors is a major determinant of open chromatin

The paper introduces ATI, a method to measure TF DNA-binding activity, and finds that few TFs with strong binding activity determine open chromatin.