Plasmodium falciparum quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1
Mariko Kanai, Sachel Mok, Tomas Yeo, Melanie J. Shears, Jin H. Jeon, Sunil Kumar Narwal, Leila Saxby Ross, Meseret T. Haile, Abhai K. Tripathi, Godfree Mlambo, Jonathan Kim, Eva Gil‐Iturbe, John Okombo, Heekuk Park, Kharizta Wiradiputri, , David A. Fidock
This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.
bioRxiv · Sep 27, 2024 · PreprintGenetics