Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1)
Tianle Chen, Francesca Vallese, Eva Gil‐Iturbe…·Emad Tajkhorshid
This study uses cryo-EM and molecular dynamics to analyze conformational transitions in AE1 and shows how PIP2 lipids inhibit transport by stabilizing the outward-facing state.