Author

Kate J. Fairhurst

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:plant (other)· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

David A. FidockiD· 3 shared Abhai K. TripathiiD· 2 shared Anne‐Catrin UhlemanniD· 2 shared Eva Gil‐IturbeiD· 2 shared Felix D. RozenbergiD· 2 shared Filippo ManciaiD· 2 shared Godfree MlamboiD· 2 shared Heekuk ParkiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

David A. FidockORCID

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Author profile →

3 papers

Recent·Most cited

Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

Arturo Casas Jr, Leah S. Imlay, Vandana Thathy, Kate J. Fairhurst, Adele M. Lehane, Aloysus K. Lawong, Ioanna Deni, Josefine Striepen, Seungheon Lee, Ashwani Kumar, Chao Xing, Hanspeter Niederstrasser, Bruce A. Posner, Benoı̂t Laleu, Susan A. Charman, , Margaret A. Phillips

This study identifies new antimalarial compounds targeting PfATP4 through phenotypic screening, showing fast-killing activity and resistance patterns consistent with PfATP4 inhibition.

ACS Infectious Diseases · Sep 8, 2025Peer-reviewedMicrobiology

Plasmodium falciparum quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1

Mariko Kanai, Sachel Mok, Tomas Yeo, Melanie J. Shears, Jin H. Jeon, Sunil Kumar Narwal, Leila Saxby Ross, Meseret T. Haile, Abhai K. Tripathi, Godfree Mlambo, Jonathan Kim, Eva Gil‐Iturbe, John Okombo, Heekuk Park, Kharizta Wiradiputri, , David A. Fidock

This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.

bioRxiv · Sep 27, 2024 · PreprintGenetics

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

Sachel Mok, Tomas Yeo, Davin Hong, Melanie J. Shears, Leila Saxby Ross, Kurt E. Ward, Satish K. Dhingra, Mariko Kanai, Jessica L. Bridgford, Abhai K. Tripathi, Godfree Mlambo, Anna Y. Burkhard, Megan R. Ansbro, Kate J. Fairhurst, Eva Gil‐Iturbe, , David A. Fidock

The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.

Science Advances · Nov 8, 2023Peer-reviewedGenomics