Haejin Angela Kwak

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

This study investigates associations between mitochondrial metabolites and metabolic syndrome in bipolar disorder, finding significant links between lactate levels and metabolic syndrome markers, while cell-free mitochondrial DNA showed no association.

The paper assesses current chemical coverage of the human Reactome, finding that 3% of proteins are targeted by chemical probes, but they cover 53% of pathways due to pathway overlap.