Richard I. Morimoto

Survey of the human proteostasis network: the ubiquitin-proteasome system

The paper provides a comprehensive survey of the ubiquitin-proteasome system (UPS) and estimates its size and scope within the human proteostasis network.

A HaloTag-4R-Tau Pulse-Chase Sensor Reveals Neddylation Inhibition Promotes Degradation of Tau in iNeurons

The paper develops a HaloTag-4R-Tau sensor to study tau clearance in iNeurons and identifies Neddylation inhibition as a method to promote tau degradation.

A default silencing mechanism restrains stress-induced genes in C. elegans

The paper identifies ZNF-236 as a key factor maintaining quiescence of stress-induced genes in C. elegans, showing that this silencing is an active genomic state, not passive.

Organization of the Proteostasis Network of Membraneless Organelles

The paper maps the proteostasis network of membraneless organelles, revealing the role of anabolic components and molecular chaperones in regulating protein conformations.

HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A

This study identifies TIMM17A as a key mediator of HSF1-driven mitochondrial biogenesis and function in cancer cells, revealing a mechanism linking HSF1 to mitochondrial protein import and energy production.

Protein-Like Polymer for Inhibition of Tau Fibril Propagation in Human-Derived Models of Neurodegeneration

This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.

Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity

This study shows that truncated RRM in TDP-43 CTFs causes structural changes in IDR, leading to toxic hetero-oligomers and cell-nonautonomous toxicity in nematodes.

Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues

This study identifies NHR-49 as a regulator of stress resilience and proteostasis in C. elegans, linking lipid homeostasis to proteotoxic stress responses.

A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway

The paper curates a list of 838 high-confidence components of the autophagy-lysosome pathway as part of a comprehensive effort to define the human proteostasis network.

Aging is associated with a systemic length-driven transcriptome imbalance

The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.

A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific Systems

The paper defines and annotates 959 genes comprising the human proteostasis network, focusing on translation, protein folding, and organelle-specific systems.