Guang Li

The paper measures de novo mutation rates in amphioxus, finding a mutation rate comparable to vertebrates and attributing high heterozygosity to large population size.

This study applies CRISPR/Cas9 for genome editing in amphioxus, showing efficient gene disruption and phenotypic effects with optimized sgRNA strategies.

This paper develops a genome-free method to improve transcriptome assembly using integrated NGS and TGS data in amphioxus, expanding gene annotations and creating a new database.

This study creates the first single-cell chromatin accessibility atlas of the lancelet, revealing regulatory elements and developmental trajectories.