Dirk Fey

Inclusion of JNK-independent drugs within multi-agent chemotherapy improves response in relapsed high-risk neuroblastoma

The paper identifies JNK-independent drugs that, when combined with standard chemotherapy, improve response in relapsed high-risk neuroblastoma by exploiting differential apoptotic network utilization.

BAX and SMAC Regulate Bistable Properties of the Apoptotic Caspase System

This study presents a mathematical model of how BAX and SMAC regulate the bistable properties of the apoptotic caspase system, validated by experimental and computational evidence.

Accurate Prediction of Kinase-Substrate Networks Using Knowledge Graphs

The paper introduces a model using knowledge graphs to predict kinase-substrate networks, achieving higher coverage and accuracy than existing methods through network-based learning.

Model-based identification of the crosstalks and feedbacks that determine the doxorubicin response dynamics of the JNK-p38-p53 network

The paper constructs a mathematical model of the JNK-p38-p53 network to identify interactions and feedbacks that determine doxorubicin response dynamics.