Paul Timpson

This paper shows that pulsed narmafotinib priming improves chemotherapy response in pancreatic cancer by reducing fibrosis and enhancing treatment efficacy.

This study identifies an opioid-mediated signaling axis in pancreatic cancer that drives extracellular matrix remodeling and tumor aggressiveness, suggesting methylnaltrexone as a potential therapeutic.

The paper identifies JNK-independent drugs that, when combined with standard chemotherapy, improve response in relapsed high-risk neuroblastoma by exploiting differential apoptotic network utilization.

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

The paper identifies a selective JNK inhibitor that blocks metastasis in triple-negative breast cancer by targeting metabolic pathways.

This paper demonstrates that controlled defocusing in low numerical aperture microscopes improves automated cell segmentation and tracking for high-throughput live-cell imaging.

This paper introduces RO-iSCAT, a technique that enables real-time, label-free tracking of membrane protrusions with high axial resolution and minimal phototoxicity.

This study identifies FGF's role in regulating Rho and Rac activity to drive lens fiber cell elongation and migration during differentiation.

This study shows that SLC7A11 in pancreatic ductal adenocarcinoma stroma, not tumor cells, predicts poor survival and that inhibiting it reduces CAF activity and tumor growth.