Melinda Halász

This study shows MYCN inhibits TrkC-induced differentiation in neuroblastoma by disrupting PKA signaling, with implications for targeting PKA to treat high-risk cases.

This study identifies a synergistic combination of DPI and MitoQ that targets mitochondrial metabolism in MYCN-amplified neuroblastoma cells, enhancing chemotherapeutic efficacy.

This study identifies diphenyleneiodonium chloride as a compound that targets MYCN-amplified neuroblastoma by inducing proteasomal degradation of MYCN and reversing mitochondrial alterations.

The paper constructs a mathematical model of the JNK-p38-p53 network to identify interactions and feedbacks that determine doxorubicin response dynamics.