Iiris Hovatta

This study shows that deleting glucocorticoid receptors in postnatal oligodendrocyte precursor cells reduces oligodendrocyte density, alters hippocampal activity, and impairs memory in adult mice.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This paper identifies SORCS3 as a novel genetic locus associated with panic disorder through a genome-wide association study in the FinnGen study and validates it in independent samples.

This study shows that human iPSC-derived pericyte-like cells with the APP Swedish mutation overproduce beta-amyloid and exhibit CAA-like features in vitro.

This study identifies 64 new risk loci for major depression, refines its genetic architecture, and shows strong genetic overlap with other psychiatric disorders and educational attainment.

This study shows chronic stress and neuronal activity remodel nodes of Ranvier in mice, linking structural changes to anxiety-like behavior.

Finnish-enriched low-frequency variants, often coding, underlie many GWAS signals across 1,932 register endpoints in 218,792 Finns; a 15-disease meta-analysis with Estonian and UK biobanks adds 30 unreported associations.

The paper shows that astrocytes from schizophrenia patients exhibit transcriptional and functional changes, including inflammation and synaptic pathway alterations, which are partially reversible with clozapine treatment.

The paper identifies rs165940 as a functional variant in the PDE4D gene associated with major mental illness in the Finnish population, particularly psychosis and cognitive domains.

The paper conducts a genome-wide association study of anxiety and stress-related disorders in the iPSYCH cohort, identifying PDE4B as consistently associated with ASRD and showing genetic overlap with other traits.