Santosh Lamichhane

m6A-Driven Intratumoral Cholesterol Biosynthesis Fuels Castration-Resistant Prostate Cancer Progression

This study identifies a functional cooperation between nuclear pore complexes and m6A signaling that promotes castration-resistant prostate cancer by linking mRNA export to cholesterol biosynthesis and androgen production.

Uncovering bioactive metabolites from the Taxus wallichiana endophyte Annulohypoxylon purpureonitens using reverse metabolomics

This study identifies bioactive metabolites from the endophytic fungus Annulohypoxylon purpureonitens using metabolomics and bioactivity screening, revealing compounds with antibacterial, antioxidant, and cytotoxic properties.

Early life gut microbial and metabolic shifts reflected in stool consistency- a gut transit time proxy

This study links gut transit time, inferred from stool consistency, to microbial metabolites and microbiota in infants, showing associations with breastfeeding, bile acid metabolism, and short-chain fatty acids.

A searchable metadata network graph for microbiome metabolomics

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

Community Curation of Microbial Metabolites Enables Biological Insights of Metabolomics Data

The paper introduces a collaborative platform for curating microbial metabolite knowledge to enhance metabolomics data interpretation.

Temporal Associations Between Human Milk Metabolites and the Infant Gut Microbiome and metabolome

This study examines how human milk metabolites relate to the infant gut microbiome and metabolome over time, finding time-dependent associations and differential influences based on dietary changes.

Faecal transplantation from exuberant toddlers increases exploratory behaviour in rats

This study transfers exuberant toddler gut microbiota to rats, increasing their exploratory behavior without affecting locomotion or social behavior.

Microbial lipid shifts in a multi-stage simulated gut

The paper uses a colon simulator to study microbial lipid shifts in the gut and validates findings using human samples.

The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds

The paper creates a spectral library of N-acyl lipids from metabolomics data, identifies novel compounds, and links them to health conditions like HIV and cognitive impairment.

Empirically establishing drug exposure records directly from untargeted metabolomics data

The paper develops a drug exposure resource from untargeted metabolomics data to identify medications without clinical records.

Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

This study examines how prenatal exposure to PFAS affects neonatal serum phospholipids and increases the risk of type 1 diabetes in offspring.

Metabolic Alterations in Human Peripheral Blood Mononuclear Cells Associate with Progression to Islet Autoimmunity and Type 1 Diabetes

The paper identifies metabolic patterns in PBMCs associated with progression to islet autoimmunity and T1D using longitudinal metabolomics and metabolic modeling.