Mansi Srivastava

An expanded evolutionary landscape of H3 histones with variants that destabilize nucleosomes and promote chromatin accessibility

This study identifies two novel H3 histone variants in Hofstenia miamia that destabilize nucleosomes and promote chromatin accessibility during regeneration.

Developmental, regenerative, and behavioral dynamics in acoel reproduction

This study characterizes the reproductive anatomy, development, regeneration, and behavior of the acoel worm Hofstenia miamia, revealing size-dependent growth rules and long-term sperm storage and self-fertilization capabilities.

Distributed neural computation and the evolution of the first brains

This study investigates the neural architecture of the acoel worm Hofstenia miamia, finding a diffuse brain with computationally pluripotent regions that support robust behavior.

Chromatin profiling data indicate regulatory mechanisms for differentiation during development in the acoel Hofstenia miamia

The paper uses ATAC-seq to analyze chromatin accessibility during embryonic development in Hofstenia miamia, identifying regulatory mechanisms and gene networks involved in differentiation.

Totipotency and high plasticity in an embryo with a stereotyped, invariant cleavage program

This paper investigates totipotency and plasticity in the acoel Hofstenia miamia, showing that isolated 4-cell stage macromeres can form whole organisms and that 8-cell stage blastomeres can reprogram to develop into a hatchling worm.

A dynamic repertoire of wound closure strategies precedes whole-body regeneration

This study identifies distinct wound closure strategies in the acoel Hofstenia miamia, revealing novel heterotypic cellular bridges and the role of actomyosin contractility in regeneration.

A spreading, multi-tissue wound signal initiates whole-body regeneration

This study identifies a spreading ERK signaling signal from muscle cells that drives regeneration in the acoel Hofstenia miamia.

A comprehensive resource for studying microRNA evolution and microRNA-mediated development and whole-body regeneration in the acoel worm Hofstenia miamia

A wound-induced differentiation trajectory for neurons

The paper identifies a wound-induced differentiation trajectory for neurons in the regenerative acoel worm Hofstenia miamia, revealing NFY's role in initiating neuronal differentiation through sox4 expression.

Regeneration recapitulates many embryonic processes, including reuse of developmental regulatory regions

This study investigates the relationship between embryonic development and regeneration in the acoel Hofstenia miamia, finding shared gene regulatory regions and distinct wound response dynamics.

PCP components control anterior and posterior regeneration, with a Prickle homolog impacting muscle organization, in the acoel Hofstenia miamia

This study identifies PCP pathway components, pk-1 and dgo-1, as essential for anterior and posterior regeneration in Hofstenia miamia, with pk-1 affecting muscle organization and gene expression in tail fragments.

Acoel single-cell atlas reveals expression dynamics and heterogeneity of a pluripotent stem cell population

The paper characterizes stem cell dynamics and heterogeneity in the acoel Hofstenia miamia using single-cell transcriptomics, revealing lineage-primed neoblast subpopulations and their response to regeneration.

Transgenesis in the acoel Hofstenia miamia

This paper develops a transgenesis protocol for Hofstenia miamia, enabling stable transgene integration and tissue-specific fluorescent expression, revealing new insights into regeneration and cell biology.

Embryonic development in the acoel Hofstenia miamia

The paper characterizes embryonic development in Hofstenia miamia with transcriptome data, identifying developmental landmarks and a novel cell internalization event.

A regulatory program for initiation of Wnt signaling during posterior regeneration

This study identifies wnt-3 as a key gene initiating Wnt signaling during posterior regeneration in the acoel worm Hofstenia miamia, revealing its role in stem cell proliferation and posterior identity establishment.