Ganesh Prabhakar Panzade

The paper identifies 3' nucleotide asymmetry as a key factor in miRNA strand selection, showing its role in guiding the loading of the guide strand into miRISC in C. elegans and human cells.

This study identifies lin-67 as a heterochronic gene that negatively regulates lin-4, let-7, and alg-1, affecting developmental timing in C. elegans.

The paper models hAGO1 mutations in C. elegans to study their impact on miRNA function and gene expression, revealing allele-specific disruptions in miRNA profiles and gene regulation.

The paper shows HRPA-1 interacts with miRNAs and miRISC components in C. elegans, affecting miRNA function and developmental timing.