Anna Zinovyeva

The paper identifies 3' nucleotide asymmetry as a key factor in miRNA strand selection, showing its role in guiding the loading of the guide strand into miRISC in C. elegans and human cells.

The paper identifies a noncanonical miRNA biogenesis pathway in C. elegans and humans that is Pol III-dependent, Microprocessor-independent, and Dicer-dependent, generating germline-enriched miRNAs like mir-1829 and miR-4521.

The paper improves miRNA strand selection predictions by calculating thermodynamic stability of duplex ends using constrained RNA folding in C. elegans.

This study identifies lin-67 as a heterochronic gene that negatively regulates lin-4, let-7, and alg-1, affecting developmental timing in C. elegans.

The paper models hAGO1 mutations in C. elegans to study their impact on miRNA function and gene expression, revealing allele-specific disruptions in miRNA profiles and gene regulation.

The paper shows HRPA-1 interacts with miRNAs and miRISC components in C. elegans, affecting miRNA function and developmental timing.

This study shows that single-nucleotide substitutions in the guide sequence block Cas9 activity in C. elegans, enabling efficient genome editing without additional blocking mutations.

The paper introduces an engineered auxin analog and AtTIR1(F79G) pair to improve the specificity and efficacy of the auxin degradation system in C. elegans.

The paper investigates the functional interactions between KH domain-containing RNA-binding proteins and microRNAs in C. elegans development, showing that many KH domain genes interact with multiple miRNAs and Argonaute alg-1.

This paper identifies HRPK-1 as an RNA-binding protein that interacts with miRNAs and modulates their activity during C. elegans development, enhancing miRNA-mediated gene repression.