Author

Frank Schwede

Biolog Life Science InstituteORCID 0000-0002-8185-3392Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Assay:metagenomics· 1

Frequent Co-Authors

François Paquet‐DurandiD· 2 shared Alexandra FachingeriD· 1 shared Andreas RentschiD· 1 shared Arianna ToloneiD· 1 shared Christian MelleiD· 1 shared Conner Langeberg· 1 shared Cyntia TaveneauiD· 1 shared Dmitry Kashin· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

François Paquet‐DurandORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

tRNA-derived second messengers confer bacterial immunity

Luis E. Valentin-Alvarado, Peter H. Yoon, Santiago C. Lopez, Yekaterina Shulgina, Conner Langeberg, Emily Armbruster, Muhammad Moez ur-Rehman, Kenneth J. Loi, Cyntia Taveneau, Isabel Esain-Garcia, Mert Koka, Zeyuan Terry Zhang, Dmitry Kashin, Frank Schwede, Gaétan Burgio, , Jennifer A. Doudna

The paper identifies a bacterial immune pathway where tRNA cleavage generates second messengers that trigger cell death via RNA-guided nuclease activity.

bioRxiv · Oct 9, 2026 · PreprintMicrobiology

Activating and inhibiting nucleotide signals coordinate bacterial anti-phage defense

Sonomi Yamaguchi, Samantha G. Fernandez, Douglas R. Wassarman, Marlen Lüders, Frank Schwede, Philip J. Kranzusch

This study identifies a bacterial anti-phage defense system, Clover, which uses nucleotide signals to dynamically regulate antiviral immunity while avoiding cellular toxicity.

Nature · Feb 18, 2026Peer-reviewedMicrobiology

Redefining the role of Ca2+-permeable channels in photoreceptor degeneration using diltiazem

Soumyaparna Das, Valerie Popp, Michael Power, Kathrin Groeneveld, Jie Yan, Christian Melle, Luke E. Rogerson, Marlly Achury, Frank Schwede, Torsten Straßer, Thomas Euler, François Paquet‐Durand, Vasilica Nache

This study shows that diltiazem enantiomers block Ca2+-influx in photoreceptors but do not prevent degeneration, challenging the role of Ca2+ in retinal degeneration.

Cell Death and Disease · Jan 10, 2022Peer-reviewedNeuroscience

Retinal degeneration: Multilevel protection of photoreceptor and ganglion cell viability and function with the novel PKG inhibitor CN238.

Arianna Tolone, Wadood Haq, Alexandra Fachinger, Andreas Rentsch, Friedrich W. Herberg, Frank Schwede, François Paquet‐Durand

This study identifies CN238, a novel PKG inhibitor, as a neuroprotective agent that preserves photoreceptor and ganglion cell viability and function in retinal degeneration models.

bioRxiv · Aug 5, 2021 · PreprintNeuroscience