Douglas R. Wassarman

Structural basis of QueC-family protein function in qatABCD anti-phage defense

This study determines the structural basis of QueC-family protein function in the qatABCD anti-phage defense system, showing their role in targeting protein substrates for N-terminal modification.

A Dimeric Rocaglate Promotes Multivalent eIF4A-RNA Assembly

This paper identifies BisRoc, a dimeric rocaglate ligand that suppresses translation more potently and specifically than monomeric RocA by promoting multivalent eIF4A-RNA assembly.

Activating and inhibiting nucleotide signals coordinate bacterial anti-phage defense

This study identifies a bacterial anti-phage defense system, Clover, which uses nucleotide signals to dynamically regulate antiviral immunity while avoiding cellular toxicity.

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

The paper identifies 7-deazapurine protein conjugation as essential for type IV CBASS immunity, revealing the roles of Cap9 and Cap10 in this process.

Cellpanelr: identify predictive biomarkers from cell line panel response data

Cellpanelr identifies mutation and expression biomarkers from cell line panel response data using DepMap datasets.

Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding

The paper uses deep mutational scanning in yeast to show that a toxic conformation of α-synuclein is stable under chemical perturbations, while mutations affecting toxicity are influenced by these perturbations.

Extending Chemical Perturbations Of The Ubiquitin Fitness Landscape In A Classroom Setting

The paper uses deep mutational scanning to explore how chemical perturbations affect ubiquitin's mutational tolerance, revealing sensitization of most positions except two.