Sarbani Samaddar

FTO-Dependent m6A RNA Dysregulation Underlies Memory Deficits Induced by Early-Life Stress

This study shows that early-life stress induces memory deficits by altering the m6A RNA epitranscriptome through FTO downregulation, affecting protein synthesis.

The RNA binding ubiquitination ligase MEX3B regulates bFGF-dependent neuronal proliferation.

This study identifies MEX3B as an RNA-binding E3 ubiquitin ligase that regulates bFGF-dependent neuronal proliferation through interactions with REST and HOTAIR.

High fat diet promotes obesity by driving miRNA dependent neurogenesis and integration of orexigenic neurons in the feeding circuitry

This study shows that high-fat diet induces miRNA-dependent neurogenesis in hypothalamic tanycytes, leading to weight gain and liver fat accumulation by promoting the integration of orexigenic neurons into the feeding circuit.

Transcriptomic analysis identifies synapse-enriched lncRNAs required for glutamatergic synapse development and fear memory consolidation.

The paper identifies synapse-enriched lncRNAs in mouse hippocampus and shows their roles in synapse development and fear memory consolidation.

CRISPR based programmable RNA editing in primary neurons

This paper develops a CRISPR-based RNA editing tool to restore Dendra2 fluorescence in neurons by editing specific nucleotides in the mRNA, enabling visualization of RNA-protein interactions.

Musleblind-1 regulates microtubule cytoskeleton in C. elegans mechanosensory neuron through tubulin mRNAs

This study identifies MBL-1 as a regulator of microtubule cytoskeleton in C. elegans mechanosensory neurons through its effects on tubulin mRNAs.

Homeostatic scaling is driven by a translation-dependent degradation axis that recruits miRISC remodelling

The paper identifies a translation-dependent degradation axis involving miRISC remodeling that drives synaptic homeostasis through the interplay of protein synthesis and degradation.