Sourav Banerjee

This paper designs and evaluates Dyr726, a brain-penetrant multi-kinase inhibitor that targets PI3Kα, receptor tyrosine kinases, and WNT signaling, showing efficacy in preclinical cancer models.

This study shows that high-fat diet induces miRNA-dependent neurogenesis in hypothalamic tanycytes, leading to weight gain and liver fat accumulation by promoting the integration of orexigenic neurons into the feeding circuit.