Author

José Cánovas

University of ChileORCID 0000-0002-5568-9576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Alberto J. M. MartíniD· 1 shared Alexis N. Martinez· 1 shared Carolina Jerez· 1 shared Claudia A. RiveraiD· 1 shared Claudio A. HetziD· 1 shared Constanza González· 1 shared Denisse Sepúlveda· 1 shared Hilal Ahmed LashueliD· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alberto J. M. MartínORCID

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1 paper

Recent·Most cited

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration

René L. Vidal, Denisse Sepúlveda, Paulina Troncoso-Escudero, Paula García-Huerta, Constanza González, Lars Plate, Carolina Jerez, José Cánovas, Claudia A. Rivera, Valentina Castillo, Marisol Cisternas-Olmedo, Sirley Leal, Alexis N. Martinez, Julia M. D. Grandjean, Sonia Donzelli, , Claudio A. Hetz

This study shows that forcing dimerization between ATF6f and XBP1s enhances UPR activity, reducing protein aggregation in neurodegenerative disease models.

Molecular Therapy · Feb 5, 2021Peer-reviewedNeuroscience