GeneticsProceedings of the National Academy of SciencesPeer-reviewed
Reducing resistance allele formation in CRISPR gene drives
Jackson Champer, Jingxian Liu, Suh Yeon Oh…·Philipp W. Messer
This study evaluates strategies to reduce resistance allele formation in CRISPR gene drives, finding that using the nanos promoter, adding a second gRNA, and using an autosomal male germline drive can lower resistance rates.
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