Author
Cornell UniversityORCID 0000-0002-2172-3297Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Jackson Champer, Emily Yang, Esther Lee, Jingxian Liu, Andrew G. Clark, Philipp W. Messer
This paper presents a CRISPR homing gene drive in Drosophila that reduces resistance allele formation by targeting a haplolethal gene, achieving high efficiency in allele spreading.
Proceedings of the National Academy of Sciences · Sep 14, 2020Peer-reviewedGenetics
Jackson Champer, Joanna Zhao, Joanna Zhao, Samuel E. Champer, Jingxian Liu, Philipp W. Messer
This study examines underdominance gene drive systems in continuous space, finding that they may fail to persist and can spread to neighboring populations despite local confinement.
ACS Synthetic Biology · Mar 6, 2020Peer-reviewedGenetics
Jackson Champer, Zhaoxin Wen, Anisha Luthra, Riona Reeves, Joan Chung, Chen Liu, Yoo Lim Lee, Jingxian Liu, Emily Yang, Philipp W. Messer, Andrew G. Clark
The paper investigates how natural genetic variation affects resistance to CRISPR gene drives in Drosophila, finding that resistance rates vary widely and are polygenic with small-effect loci.
Genetics · Mar 27, 2019Peer-reviewedGenetics
Jackson Champer, Jingxian Liu, Suh Yeon Oh, Riona Reeves, Anisha Luthra, Nathan Oakes, Andrew G. Clark, Philipp W. Messer
This study evaluates strategies to reduce resistance allele formation in CRISPR gene drives, finding that using the nanos promoter, adding a second gRNA, and using an autosomal male germline drive can lower resistance rates.
Proceedings of the National Academy of Sciences · May 7, 2018Peer-reviewedGenetics
Jackson Champer, Riona Reeves, Suh Yeon Oh, Chen Liu, Jingxian Liu, Andrew G. Clark, Philipp W. Messer
PLoS Genetics · Jul 20, 2017Peer-reviewedGenetics