Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis
Ikki Sakuma, Rafael Calais Gaspar, Ali R. Nasiri, Sylvie Dufour, Mario Kahn, Jie Zheng, Traci E. LaMoia, Mateus T. Guerra, Yuki Taki, Yusuke Kawashima, Dean Yimlamai, Mark Perelis, Daniel F. Vatner, Kitt Falk Petersen, Maximilian Huttasch, , Gerald I. Shulman
Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.
Proceedings of the National Academy of Sciences · May 1, 2025Peer-reviewedPathology✦ In-depth digest