Author

Ikki Sakuma

Chiba UniversityORCID 0000-0002-9605-1173Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Ali R. NasiriiD· 1 shared Birgit KnebeliD· 1 shared Daniel F. VatneriD· 1 shared Dean YimlamaiiD· 1 shared Gerald I. ShulmaniD· 1 shared Jie Zheng· 1 shared Kitt Falk PeterseniD· 1 shared Mario KahniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPathology

Ali R. NasiriORCID

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1 paper

Recent·Most cited

PathologyProceedings of the National Academy of SciencesPeer-reviewedMay 1, 2025

✦ In-depth digest

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

Ikki Sakuma, Rafael Calais Gaspar, Ali R. Nasiri…·Gerald I. Shulman

Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.

46 citationstop 1%

mousehuman

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