Author

Joanna Brzostek

National University of SingaporeORCID 0000-0002-5621-2649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Bing XuiD· 1 shared Björn F. LillemeieriD· 1 shared Bowen HouiD· 1 shared Changchun XiaoiD· 1 shared Chaonan Yan· 1 shared Chenghao HuangiD· 1 shared Cong YuiD· 1 shared Daniel Peschkov· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

Bing XuORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 28, 2026

Knockout and re-expression system for mutant analysis in primary mouse T cells

Vasileios Morfos, Meredith C. Frie, Daniel Peschkov…·Joanna Brzostek

This paper introduces a knockout and re-expression system for analyzing mutant phenotypes in primary mouse T cells, showing improved integration of mutant proteins and validation for TCR and Zap70 studies.

DOI 10.64898/2026.08.25.746944

mouseproteomics

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ImmunologybioRxivPreprintFeb 17, 2025

Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

Jian Tang, Xian Jia, Taoling Zeng…·Guo Fu

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

2 citations

mousebulk RNA-seq

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