Author

Taoling Zeng

Xiamen UniversityORCID 0000-0002-2697-5960Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Hongrui WangiD· 2 shared Baoding ZhangiD· 1 shared Bing XuiD· 1 shared Bowen HouiD· 1 shared Caiming WuiD· 1 shared Changchun XiaoiD· 1 shared Chaonan Yan· 1 shared Chenghao HuangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Hongrui WangORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

Taoling Zeng, Tingting Jiang, Baoding Zhang, Ting Zhang, Wanjun Dai, Xun Yin, Yunzhan Li, Zhuoran Yu, Caiming Wu, Yaying Wu, Ximin Chi, Xianming Deng, Hongrui Wang

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Acta Pharmaceutica Sinica B · Jul 25, 2025Peer-reviewedCancer Biology

Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

Jian Tang, Xian Jia, Taoling Zeng, Yuzhou Bao, Yanyan Hu, Junchen Dong, Xiaozheng Xu, Xiao Lei Chen, Yongchao Liu, Jiayu Wang, Bowen Hou, Yuzhen Zhu, Guofeng Fu, Qi‐Fan Zheng, Yongling Chen, , Guo Fu

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

bioRxiv · Feb 17, 2025 · PreprintImmunology