Larry E. Wagner

Functional investigation of a putative calcium-binding site involved in the inhibition of inositol 1,4,5-trisphosphate receptor activity

This study investigates a putative Ca2+ binding site in IP3R that modulates channel activity, showing that mutations at this site alter Ca2+ sensitivity and puff dynamics.

Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjogrens syndrome

This study identifies dysregulated Ca2+ signaling and mitochondrial dysfunction in a mouse model of early Sjogrens syndrome, leading to reduced fluid secretion.