Author

David I. Yule

University of Rochester MedicineORCID 0000-0002-6743-0668Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

David I. Yule1 paper

Biology Disciplines

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Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Larry E. WagneriD· 2 shared Takahiro TakanoiD· 2 shared Catherine E. OvittiD· 1 shared Eri O. MaruyamaiD· 1 shared Guizhen FaniD· 1 shared Harini BagavantiD· 1 shared Helen P. MakarenkovaiD· 1 shared Hitoshi Uchida· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Larry E. WagnerORCID

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3 papers

Recent·Most cited

Ascl3+ ionocytes in murine salivary gland ducts are innervated sensory cells that display unique calcium signaling characteristics and contribute to the composition of saliva

Hitoshi Uchida, Eri O. Maruyama, Takahiro Takano, Marit H. Aure, Melissa F Glasner, Zamira Guerra Soares, Roberta C. Faustoferri, Kaye Thomas, Helen P. Makarenkova, David I. Yule, Catherine E. Ovitt

bioRxiv · Aug 28, 2025 · PreprintPhysiology

Functional investigation of a putative calcium-binding site involved in the inhibition of inositol 1,4,5-trisphosphate receptor activity

Vikas Arige, Larry E. Wagner, Sundeep Malik, Mariah R. Baker, Guizhen Fan, Irina I. Serysheva, David I. Yule

This study investigates a putative Ca2+ binding site in IP3R that modulates channel activity, showing that mutations at this site alter Ca2+ sensitivity and puff dynamics.

Journal of Biological Chemistry · Feb 11, 2025Peer-reviewedBiochemistry

Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjogrens syndrome

Kai‐Ting Huang, Larry E. Wagner, Takahiro Takano, Xiao-Xuan Lin, Harini Bagavant, Umesh S. Deshmukh, David I. Yule

This study identifies dysregulated Ca2+ signaling and mitochondrial dysfunction in a mouse model of early Sjogrens syndrome, leading to reduced fluid secretion.

eLife · May 24, 2024Peer-reviewedPhysiology