Vikas Arige

Dynamic regulation of cystathionine gamma-lyase expression during normoxia, ischemia, and reperfusion in liver: interplay of transcription factors, microRNAs, and histone modifications

This study identifies the molecular mechanisms regulating CTH expression during ischemia and reperfusion, revealing the roles of transcription factors, microRNAs, and histone modifications.

Functional investigation of a putative calcium-binding site involved in the inhibition of inositol 1,4,5-trisphosphate receptor activity

This study investigates a putative Ca2+ binding site in IP3R that modulates channel activity, showing that mutations at this site alter Ca2+ sensitivity and puff dynamics.

MicroRNA-27a is a key modulator of cholesterol biosynthesis

This study identifies miR-27a as a regulator of Hmgcr and cholesterol biosynthesis, showing its role in modulating plasma cholesterol levels in mice.

Hypoxia mediated regulation of mitochondrial transcription factors: Implications of hypertensive renal physiology

This study investigates how hypoxia regulates mitochondrial transcription factors in hypertensive rats and cultured kidney cells, finding increased expression of HIF-1, PGC-1, mtTFs, and OXPHOS proteins under hypoxic conditions.

Functional promoter polymorphisms govern the differential expression of HMG-CoA Reductase gene in rat models of essential hypertension

The paper identifies promoter polymorphisms in the Hmgcr gene that reduce its expression in rat hypertension models by altering transcription factor binding.