Author

Chaoqi Chen

Chinese Academy of SciencesORCID 0000-0002-5645-7718Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Fanglin LiiD· 1 shared Fengru Qiu· 1 shared Fengyu DuiD· 1 shared Likun GongiD· 1 shared Liying CheniD· 1 shared Rong Zhang· 1 shared Rongchen Liu· 1 shared Runqiu CheniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Fanglin LiORCID

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1 paper

Recent·Most cited

CTLA-4 inhibitors drive colitis through metabolic reprogramming-mediated Treg/Th17 imbalance

Zhiying Li, Shanna Wu, Rongchen Liu, Runqiu Chen, Fanglin Li, Rong Zhang, Yiting Wang, Chaoqi Chen, Xinhang Zheng, Fengru Qiu, Liying Chen, Yaqi Zhao, Fengyu Du, Likun Gong, Yiru Long

This study identifies metabolic reprogramming as a mechanism by which CTLA-4 inhibitors cause colitis, showing that metformin can alleviate this toxicity without affecting antitumor efficacy.

bioRxiv · Jan 21, 2026 · PreprintPharmacology & Toxicology