Germline Targeted Baboon Apolipoprotein L-1 Protects Mice Against African Trypanosomes
Sara Fresard, Sarah J. Pangburn, Kayla Leiss, Daphne Boodwa-Ko, Daniella Kovacsics, Christopher J. Schoenherr, Jeremy S. Rabinowitz, Aris N. Economides, Li Li, Weigang Qiu, B. González-Baradat, Alessandro Rosa, Russell P. Thomson, Jayne Raper, Joseph Verdi
This study generates trypanosome-resistant murine models expressing primate APOL1 proteins to investigate their role in immunity, finding that baboon APOL1 provides partial protection but with limited expression, while a chimeric APOL1 variant shows protection with a fitness cost.
Proceedings of the National Academy of Sciences · Mar 27, 2026Peer-reviewedMicrobiology