Yun Wei

Sequence-Defined Digital Bottlebrush Polymers for Programmable Oligonucleotide Delivery

This paper develops sequence-defined digital bottlebrush polymers for targeted oligonucleotide delivery, achieving organ-specific therapeutic effects in a mouse model.

Tumor-tropic E. coli engineered as living T and NK cell engagers

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

Bottlebrush Polymer Conjugates for Enhanced Antisense Oligonucleotide Therapy in Myotonic Dystrophy Type 1

This paper demonstrates that bottlebrush polymer conjugates enhance antisense oligonucleotide therapy for DM1, improving muscle distribution and splicing correction in a mouse model.

CRISPR/Cas9-mediated germline mutagenesis in the subsocial parasitoid wasp, Sclerodermus guani

This study uses CRISPR/Cas9 to achieve germline gene knockout in the subsocial wasp Sclerodermus guani, revealing a white-eye phenotype in homozygous mutants.

Making Aptamers More Antibody-like: Targeting AXL in Vivo Using a Bottlebrush Polymer-Conjugated Aptamer

This paper develops a bottlebrush polymer-conjugated aptamer (pacDNA) to improve aptamer stability and efficacy in targeting AXL, showing reduced cancer cell migration and tumor growth in a xenograft model.

Bottlebrush polymers with sequence-controlled backbones for enhanced oligonucleotide delivery

This paper develops sequence-controlled PEG bottlebrush polymers for enhanced oligonucleotide delivery, showing improved cellular uptake and in vivo antisense activity through optimized chemical modifications.