The paper develops a spatially and temporally resolved model of small intestinal crypt maintenance using integrated approaches, revealing CBC cells as the main driver of tissue replenishment.

Developmental Cell · Jan 9, 2025Peer-reviewedCell Biology

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

Laura Maarit Pikkupeura, Raul Bardini Bressan, Jordi Guiu, Yun Chen, Martti Maimets, Daniela Mayer, Pawel J. Schweiger, Stine Lind Hansen, Grzegorz Jerzy Maciag, Hjalte List Larsen, Kadi Lõhmussaar, Marianne Terndrup Pedersen, Joji Marie Teves, Jette Bornholdt, Vladimı́r Beneš, , Kim Bak Jensen

Science Advances · Jul 12, 2023Peer-reviewedDevelopmental Biology

Benchmarking brain organoid recapitulation of fetal corticogenesis

Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Alejandro Tobon, Erika Tenderini, Sara Sebastiani, Flavia Troglio, Michele Gabriele, Raul Bardini Bressan, Steven M. Pollard, William T. Gibson, Giuseppe Testa

This study benchmarks brain organoid gene co-expression patterns against fetal corticogenesis to assess their alignment with in vivo development.

Translational Psychiatry · Dec 20, 2022Peer-reviewedDevelopmental Biology

Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells

Mário A. F. Soares, Diogo S. Soares, Vera Teixeira, Abeer Heskol, Raul Bardini Bressan, Steven M. Pollard, Raquel A. Oliveira, Diogo S. Castro

The paper shows that Brn2 and Ascl1 differentially bind mitotic chromosomes, influencing the timing of transcriptional reactivation during the mitosis-to-G1 transition.

bioRxiv · Feb 17, 2021Developmental Biology

From Cohorts to Molecules: Adverse Impacts of Endocrine Disrupting Mixtures

Lina Birgersson, Gábor Borbély, Nicolò Caporale, Pierre‐Luc Germain, Michelle Leemans, Filip Rendel, Giuseppe Alessandro D’Agostino, Raul Bardini Bressan, Francesca Cavallo, Nadav Even Chorev, Vesna Munić Kos, Maddalena Lazzarin, Steven M. Pollard, Birgitta Sundström, Alejandro Lopez Tobon, , Giuseppe Testa

The paper identifies EDC mixtures linked to adverse health outcomes and shows they disrupt gene regulatory networks in vitro and in vivo.

bioRxiv · Oct 23, 2017 · PreprintMolecular Biology