Raquel A Oliveira

Distinct regulation across the transcription cycle drives mitotic transcriptional silencing

The paper quantifies how transcription is silenced during mitosis in Drosophila embryos by analyzing initiation, elongation, and termination kinetics.

DNA catenation is essential for Sister Chromatid Cohesion

This study shows DNA catenation is essential for sister chromatid cohesion in budding yeast and metazoan chromosomes, as it provides force resistance necessary for accurate chromosome segregation.

TTF2 prevents premature rRNA synthesis during mitotic exit

This study shows TTF2 prevents premature rRNA synthesis during mitotic exit by regulating RNA Polymerase I reactivation and nucleolar protein recruitment.

Removal of nascent transcripts by TTF2 is required for sister chromatid resolution in human cells.

This study shows that TTF2 removal causes mitotic defects by retaining transcription on chromatin, leading to sister chromatid resolution failure and genome instability.

Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells

The paper shows that Brn2 and Ascl1 differentially bind mitotic chromosomes, influencing the timing of transcriptional reactivation during the mitosis-to-G1 transition.

Delayed aneuploidy stress response of neural stem cells impairs adult lifespan in flies

The paper shows that delayed aneuploidy stress response in neural stem cells during Drosophila development leads to motor defects and reduced lifespan.