Author

Xiaoxin Hao

Baylor College of MedicineORCID 0000-0001-8763-3529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:scRNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

Fengshuo LiuiD· 4 shared Hilda L. ChaniD· 4 shared Xiang H.-F. ZhangiD· 4 shared Charlotte Helena RivasiD· 3 shared Dane K. HoffmaniD· 3 shared Liqun YuiD· 3 shared Luis Becerra-DomingueziD· 3 shared Weijie ZhangiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Fengshuo LiuORCID

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4 papers

Recent·Most cited

Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity

Yang Gao, Emmanuel Anning, Linhua Wang, Yating Cheng, Ling Wu, Jun Wang, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Jun Liu, Liqun Yu, Yunfeng Ding, Weijie Zhang, David Glenn Edwards, Yi-Hsuan Wu, , Xiang H.-F. Zhang

This study identifies an early neutrophil interferon program that predicts resistance to anti-PD1 therapy and limits durable anti-tumor immunity.

bioRxiv · Oct 1, 2026 · PreprintCancer Biology

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

Fengshuo Liu, Yunfeng Ding, Zhan Xu, Xiaoxin Hao, Tianhong Pan, George E. Miles, Siyue Wang, Yi-Hsuan Wu, Jun Liu, I. L. Bado, Weijie Zhang, Ling Wu, Yang Gao, Liqun Yu, David G. Edwards, , Xiang H.-F. Zhang

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Cell Genomics · May 23, 2025Peer-reviewedCancer Biology

CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

Xueying Yuan, Xiaoxin Hao, Hilda L. Chan, Na Zhao, Diego A. Pedroza, Fengshuo Liu, Kang Le, Alex J. Smith, Sebastian J. Calderon, Nadia Lieu, Michael Soth, PHILIP G. JONES, Xiang H.-F. Zhang, Jeffrey M. Rosen

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

JCI Insight · Sep 17, 2024Peer-reviewedCancer Biology

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Zhan Xu, Fengshuo Liu, Yunfeng Ding, Tianhong Pan, Yi-Hsuan Wu, Jun Liu, I. L. Bado, Weijie Zhang, Ling Wu, Yang Gao, Xiaoxin Hao, Liqun Yu, David G. Edwards, Hilda L. Chan, Sergio Aguirre, , Xiang H.-F. Zhang

bioRxiv · May 7, 2024 · PreprintCancer Biology