Matthias S. Leisegang

The transaminase-omega-amidase pathway is a redox switch in glutamine metabolism that generates alpha-ketoglutarate

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

Haematopoietic loss of KDM6A impairs cardiac recovery in heartfailure via epigenetic reprogramming of myeloid cells

This study shows that loss of KDM6A in hematopoietic cells impairs cardiac recovery after heart failure by causing epigenetic changes in myeloid cells that increase inflammation and worsen cardiac outcomes.

Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents

The paper investigates the impact of miRNA losses in rodents, showing multi-level gene regulation restructuring and evolutionary consequences.

GeneCOCOA: Detecting context-specific functions of individual genes using co-expression data

GeneCOCOA identifies context-specific functions of individual genes using co-expression data and curated functional gene sets, outperforming existing methods in gene-disease association recall.

Long non-coding RNAs direct the SWI/SNF complex to cell-specific enhancers

This study identifies long non-coding RNAs (lncRNAs) as guides for the SWI/SNF complex to cell-specific enhancers, revealing a mechanism for chromatin accessibility and gene expression control.

Detection of statistically robust interactions from diverse RNA-DNA ligation data

The paper introduces RADIAnT, a computational pipeline for detecting RNA-DNA interactions from ligation data, showing improved accuracy in identifying Malat1-DNA interactions and dynamic chromatin-associated RNAs.

The aging-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4

This study identifies circPLOD2 as a hypoxia-regulated circRNA that modulates pericyte function by regulating KLF4, affecting proliferation and vascular interactions.

The endothelial-specific LINC00607 mediates endothelial angiogenic function

This study identifies LINC00607 as an endothelial-specific lncRNA that supports angiogenic function by interacting with BRG1 to regulate chromatin accessibility and ERG target gene transcription.

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

The paper identifies HIF1α-AS1 as a DNA:DNA:RNA triplex-forming lncRNA that interacts with the HUSH complex to repress gene expression and modulates angiogenesis in pulmonary hypertension.

Integrative analysis of epigenetics data identifies gene-specific regulatory elements

This paper introduces a new method to identify gene-specific regulatory elements by integrating epigenomics data and demonstrates its application in prioritizing doxorubicin-resistance genes.