Author
The Francis Crick InstituteORCID 0000-0002-5703-9710Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Elizabeth Larose Cadieux, Nana Mensah, Carla Castignani…·Peter Van Loo
This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.
Saioa López, Emilia L. Lim, Ariana Huebner…·Nicholas McGranahan
The paper investigates how whole genome doubling (WGD) in cancer may mitigate Muller’s Ratchet by reducing negative selection on mutations in essential genes after duplication.
Collin M. Blakely, Thomas B.K. Watkins, Wei Wu…·Trever G. Bivona
The paper investigates genetic epistasis in EGFR-mutant lung cancers using over 2,000 cases, showing that genetic combinations, not single drivers, dominate tumor progression and clinical outcomes.