Author

Michelle Dietzen

The Francis Crick InstituteORCID 0000-0002-6853-7563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:statistical model· 2 Research Focus:deconvolution· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Charles SwantoniD· 2 shared Gareth A. WilsoniD· 2 shared Mariam Jamal‐HanjaniiD· 2 shared Nicholas McGranahaniD· 2 shared Thomas B.K. WatkinsiD· 2 shared Andrew FeberiD· 1 shared Andrew RowaniD· 1 shared Annelien VerfaillieiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Charles SwantonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Copy number-aware deconvolution of tumor-normal DNA methylation profiles

Elizabeth Larose Cadieux, Nana Mensah, Carla Castignani, Miljana Tanić, Gareth A. Wilson, Michelle Dietzen, Pawan Dhami, Heli Vaikkinen, Annelien Verfaillie, Cristina Cotobal, Toby M. Baker, Thomas B.K. Watkins, Selvaraju Veeriah, Mariam Jamal‐Hanjani, Nnennaya Kanu, , Peter Van Loo

This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.

bioRxiv · Nov 3, 2020 · PreprintGenomics

Whole Genome Doubling mitigates Muller’s Ratchet in Cancer Evolution

Saioa López, Emilia L. Lim, Ariana Huebner, Michelle Dietzen, Thanos P. Mourikis, Thomas B.K. Watkins, Andrew Rowan, Sally M. Dewhurst, Nicolai J. Birkbak, Gareth A. Wilson, Mariam Jamal‐Hanjani, Charles Swanton, Nicholas McGranahan

The paper investigates how whole genome doubling (WGD) in cancer may mitigate Muller’s Ratchet by reducing negative selection on mutations in essential genes after duplication.

bioRxiv · Jan 7, 2019 · PreprintGenomics