Author
University College HospitalORCID 0000-0003-1212-1259Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Jo-Anne A M Wilson, Rachel Walters, Greg Contento…·Rachel Clare Chambers
This study shows that the TGF-β1/mTORC1 signalling axis regulates the transcriptional identity of CTHRC1+ fibroblasts in IPF, supporting mTORC1 as a therapeutic target.
Ezequiel Dantas, Anirudh Murthy, Jeshua Kim…·Marcus DaSilva Goncalves
This study shows that JAK1/2 inhibition with ruxolitinib improves survival and body weight in lung cancer models by increasing food intake and restoring metabolic function.
Imran Noorani, Magnus J. Haughey, Jens Luebeck…·Benjamin Werner
This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.
Elizabeth Larose Cadieux, Nana Mensah, Carla Castignani…·Peter Van Loo
This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.
Saioa López, Emilia L. Lim, Ariana Huebner…·Nicholas McGranahan
The paper investigates how whole genome doubling (WGD) in cancer may mitigate Muller’s Ratchet by reducing negative selection on mutations in essential genes after duplication.